Blog
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Glycosides in MS/MS: Characteristic Fragments and Neutral Losses
The 162 Da loss is one of the first diagnostic patterns any analyst learns: see it in an MS/MS spectrum…
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Why Permethylated N-Glycans Show −32 and −54 Da Peaks
You run a routine permethylation of PNGase F-released N-glycans, and the spectrum carries a second series of peaks sitting 32…
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DMSO in LC-MS: Signal Booster or Source of Peak Distortion?
LC–MS method development DMSO in LC–MS: Signal Booster or Source of Peak Distortion? Dimethyl sulfoxide solves compounds that refuse to…
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Literature Watch #1: Salt Effects on PFAS, Derivatisation After the Column, and Blades Without Electrospray
Literature Watch · Issue 1 · Covering late July to early August 2026 A short, opinionated round-up of new analytical…
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RP-LC vs HILIC vs SFC vs IC-HRMS: Which Method Wins?
Non-target screening · Water analysis RP-LC vs HILIC vs SFC vs IC-HRMS: Why No Single Method Sees Everything A four-laboratory…
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Sample Solvent and Gradient Mismatch in HPLC: Why Peaks Split
HPLC troubleshooting Sample Solvent and Gradient Mismatch in HPLC: Why Peaks Split, Front or Broaden A new column is installed,…
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How Mass Spectrometry Sensitivity Improved: From Femtomoles to Single Cells
Mass spectrometry fundamentals How Mass Spectrometry Sensitivity Improved: From Femtomoles to Single Cells In 1989, electrospray protein analysis typically required…
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Latest HRMS Systems for 2027: Sensitivity, Robustness and Real-World Benchmarks
Updated August 11, 2026: This 2027 buyer’s guide compares the newest high-end HRMS platforms officially available from five major LC-MS…
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Latest Triple Quadrupole LC-MS Systems in 2026: Sensitivity, Robustness and Real-World Benchmarks
Triple quadrupole LC-MS/MS remains the preferred platform for targeted quantitation when a laboratory needs high sensitivity, selectivity and throughput. The…
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Ion Suppression in LC–MS: Causes, Diagnosis and Solutions
Method Development · Mass Spectrometry · Sample Preparation · 14–20 minutes Ion suppression is one of the most dangerous LC–MS…
Categories
- Characteristic Fragments (8)
- HPLC & LC Troubleshooting (4)
- HPLC Fundamentals (6)
- LC-MS Troubleshooting (1)
- Literature Watch (2)
- Mass Spectrometry (19)
- Method Development (14)
- Resources (1)
Recent posts
- Literature Watch #2: Breakthrough Volumes, Therapeutic Drug Monitoring, and Sorbents That Do the Cleanup for You
- IC or HILIC for Very Polar Analytes: A Decision Guide
- Proteomics Explained: How Measuring Proteins Is Changing Medicine—and What Comes Next
- Glucuronides and Sulfates in LC-MS: Characteristic Fragments
- Common Neutral Losses in LC-MS/MS: A Reference Table
- Triazole Fungicides in LC-MS: A Class Without a Class Ion
- Lipid Classes in LC-MS: Characteristic Fragment Ions and Neutral Losses
- Sulfonamides: Characteristic Fragment Ions and Neutral Losses