Blog
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Literature Watch #2: Breakthrough Volumes, Therapeutic Drug Monitoring, and Sorbents That Do the Cleanup for You
Literature Watch · Issue 2 · Covering 9–15 August 2026 A short round-up of new papers worth a look. This…
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IC or HILIC for Very Polar Analytes: A Decision Guide
Method development · Column selection IC or HILIC for Very Polar Analytes: A Decision Guide Your analyte elutes in the…
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Proteomics Explained: How Measuring Proteins Is Changing Medicine—and What Comes Next
Last updated: September 2026 The human genome is often described as a blueprint. But a blueprint does not tell us…
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Glucuronides and Sulfates in LC-MS: Characteristic Fragments
Phase II conjugates are the most rewarding class in this series to screen for, because the conjugating group is identical…
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Common Neutral Losses in LC-MS/MS: A Reference Table
The class-specific signatures covered elsewhere in this series — 156.0114 for sulfonamides, 184.0733 for phosphatidylcholines, 176.0321 for glucuronides — tell…
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Triazole Fungicides in LC-MS: A Class Without a Class Ion
Sulfonamides hand you a class ion: m/z 156.0114, in essentially every member. Triazole fungicides do not. They share a structural…
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Lipid Classes in LC-MS: Characteristic Fragment Ions and Neutral Losses
Lipids are the clearest case in all of LC-MS of a compound class announcing itself. Every phosphatidylcholine, whatever its fatty…
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Sulfonamides: Characteristic Fragment Ions and Neutral Losses
Every sulfonamide fragments to the same handful of ions, regardless of the heterocycle attached to it. That makes the class…
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When Groups Move: Gas-Phase Migration and Why Fragments Can Lie
Every structural interpretation of an MS/MS spectrum rests on one unspoken assumption: that the fragments reflect the connectivity of the…
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Chlorine Isotopes and the +16 Hydroxylation Shift: Reading Mass Differences
Two of the most productive signals in mass spectrometry are not fragments at all. One is a pattern: chlorine announces…
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- Characteristic Fragments (8)
- HPLC & LC Troubleshooting (4)
- HPLC Fundamentals (6)
- LC-MS Troubleshooting (1)
- Literature Watch (2)
- Mass Spectrometry (19)
- Method Development (14)
- Resources (1)
Recent posts
- Literature Watch #2: Breakthrough Volumes, Therapeutic Drug Monitoring, and Sorbents That Do the Cleanup for You
- IC or HILIC for Very Polar Analytes: A Decision Guide
- Proteomics Explained: How Measuring Proteins Is Changing Medicine—and What Comes Next
- Glucuronides and Sulfates in LC-MS: Characteristic Fragments
- Common Neutral Losses in LC-MS/MS: A Reference Table
- Triazole Fungicides in LC-MS: A Class Without a Class Ion
- Lipid Classes in LC-MS: Characteristic Fragment Ions and Neutral Losses
- Sulfonamides: Characteristic Fragment Ions and Neutral Losses